本文提出,肿瘤是一种蛋白质组病,并根据肿瘤比较蛋白质组、表达蛋白质组、功能蛋白质组和结构蛋白质组研究进展,从肿瘤发生发展过程中蛋白质(组)表达水平及状态、蛋白质翻译后修饰、蛋白质相互作用及网络调控等三个方面进行阐述.该观点的提出,将为肿瘤发病机制的研究开辟新的领域,为肿瘤的诊断(如生物标志物筛选)和筛选(如药物新靶标)提供新的思路,具有重要的科学意义和临床应用价值.
由于心肌坏死后局部组织缺血、缺氧,引起氧化应激和炎性反应,致使移植干细胞的生存和分化能力受到一定影响。胰岛素样生长因子-1、肝细胞生长因子、骨形态发生蛋白-2等细胞因子可通过与其受体结合,激活P13-K/Akt信号转导途径,从而介导干细胞在移植微环境中的存活,有利于移植干细胞向心肌分化。
目的:拟通过调节糖原合酶激酶3(GSK-3)活性,检测蛋白磷酸酯酶2A催化亚基去甲基化水平(dmL309-PP2AC)以及相关分子的变化,进一步阐明GSK-3调节PP2A活性的分子机制。方法:将选用小鼠神经瘤细胞株,给予PI3-K抑制剂
Objective:We

previously reported that inhibition of mitochondrial permeability transition pore(mPTP) is involved in the neuroprotection induced by sevoflurane postconditioning(SPost).However, the upstream mechanisms remain unclear.In the present study,we examined the hypothesis that the neuroprot…
Glycogen synthase kinase 3b (GSK-3b) is a serine/threonine protein kinase involved in the modulation of the inflammatory response. Dysregulation selleck抑制剂 of GSK-3b has been implicated in the pathogenesis of several diseases including sepsis. Here, we investigate the effects of two chemically distinct

GSK…
Diabetes and oxidative stress:preventive role of physical exercise Mustafa Atalay, Niku Oksala, Jani Lappalainen, Osmo Hanninen, Chandan K. Sen ( University of Ruopio, Finland. Mustafa. [email protected]) Oxidative stress, an imbalance between the generation of reactive oxygen species and antioxidant…
Effect of ganoderma lucidum spores 时间 powder on TNF – α and ET -1 in the hippocampi of epilepsy rat Shuang Zhao ,Shu – qiu Wang ,Sheng – chang Zhang ,Xiao – ru Ma ,Ting Zhang ( Postgraduate of Grade 2003,Jiamusi University, Jiamusi 154007, China; Department of Pathophysiology Basic Medical College o…
目的:探讨2型糖尿病对舒芬太尼后处理及GSK-3β蛋白抑制剂SB216763减轻大鼠心肌缺血再灌注损伤作用的影响方法:健康雄性清洁级SD大鼠80只,体重1 80-200g,随机分为糖尿病造模组和正常组各40只。2型糖尿病模型的制备采用高脂饲料喂养诱导胰岛素抵抗加一次性腹腔注射链脲佐菌素35mg/kg的方法。正常组大鼠予以普通大鼠饲料,各饲养8周后进入实验,各随机分为4组,共8组(n=6):非糖尿病假手术组(NDM-S组)、非糖尿病缺血再灌注组(NDM-IR组)、非糖尿病舒芬后处理组(NDM-SP组)、非糖尿病SB216763处理组(NDM-SB组)、糖尿病假手术组(DM-S组)、糖尿病缺血再灌…
Introduction Myocardial ischemia reperfusion injury can be reduced by several interventions,including

LDN 193189 ischemic preconditioning(IPC) and volatile anesthetic preconditioning,in animal hearts and human hearts. However,recent studies have indicted that several pathological conditions,such as
目的:最近的研究表明TRIM家族蛋白MG53在心肌保护中发挥重要作用,但是很少的研究探讨MG53在七氟烷后处理抗心肌缺血再灌注损伤中的作用。本文试图研究MG53在大鼠I/R模型中七氟烷后处理心肌保护作用中的作用和机制。方法:应用Langendorff系统,离体大鼠心脏经历40min全心缺血120min再灌注,后处理组在复灌开始10给予2.5%七氟烷后处理。记录左心室血流动力学参数,测量心肌梗死面积,心肌MG53,Akt,p-Akt,ERK1/2,p-ERK1/2),GSK3β,p-GSK3β表达量。结果:相比对照组,七氟烷后处理组血流动力学明显改善,梗死面积明显减少,并且这种变化可以被LY29…
Traumatic brain injury (TBI) is often caused by the accidents to damage the brain. TBI may induce glutamate excitotoxicity and lead to neuronal and glial cell death. In this study, we investigated the mechanism of cell death during secondary damage of TBI and the protective effect of resveratrol. No…